Chlorthalidone Reduces Cardiovascular Events Compared With Hydrochlorothiazide
نویسندگان
چکیده
منابع مشابه
Population Science/Epidemiology Chlorthalidone Reduces Cardiovascular Events Compared With Hydrochlorothiazide A Retrospective Cohort Analysis
There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management. The objective of this analysis was to evaluate the effects of CTD compared with HCTZ on cardiovascular event (CVE) rates. We performed a retrospective observational cohort study from the Multiple Risk Factor Intervention Trial data set from the National Hear...
متن کاملChlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis.
There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management. The objective of this analysis was to evaluate the effects of CTD compared with HCTZ on cardiovascular event (CVE) rates. We performed a retrospective observational cohort study from the Multiple Risk Factor Intervention Trial data set from the National Hear...
متن کاملChlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: systematic review and network meta-analyses.
Hydrochlorothiazide (HCTZ) is widely used for hypertension, and prescriptions for HCTZ outnumber those for chlorthalidone (CTDN) by >20-fold in 2 recent surveys. Some have recently expressed a preference for CTDN. However, head-to-head trials testing the effect of the 2 drugs on cardiovascular events (CVEs) are lacking. We conducted a systematic review of randomized trials in which 1 arm was ba...
متن کاملPotency of office blood pressure from hydrochlorothiazide and chlorthalidone fails to explain cardiovascular events.
Potency of Office Blood Pressure From Hydrochlorothiazide and Chlorthalidone Fails to Explain Cardiovascular Events To the Editor: Peterzan et al provide a meta-analysis that examines the doseresponse relationships on blood pressure for thiazide-like diuretics and find that chlorthalidone is 3 times more potent than hydrochlorothiazide (HCTZ) in reducing office systolic blood pressure. Their pr...
متن کاملChlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension.
Evidence-Based Answer Chlorthalidone produces slightly greater reductions in blood pressure compared with hydrochlorothiazide (HCTZ), but it is associated with greater declines in serum potassium levels. (Strength of Recommendation [SOR]: C, based on a meta-analysis of disease-oriented evidence.) Chlorthalidone lowers the risk of cardiovascular events about 18% more than HCTZ at the same achiev...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.110.161505